background:
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGSLC3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
Function:
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGSLC3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
Subunit:
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via SLCterminus); the interaction stimulates TFAP2B-transcriptional activity.
Subcellular Location:
Nucleus.
Post-translational modifications:
Sumoylated on Lys-10; which inhibits transcriptional activity.
Similarity:
Belongs to the AP-2 family.
Database links:
Entrez Gene: 419327 Chicken
Entrez
Gene: 7022 Human
Entrez Gene: 21420 Mouse
Entrez Gene: 362280 Rat
Omim: 601602 Human
SwissProt: Q92754 Human
SwissProt: Q61312 Mouse
Unigene: 473152 Human
Unigene: 3629 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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