background:
Sertad1 acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).
Function:
Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).
Subunit:
Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4.
Similarity:
Contains 1 SERTA domain.
Database links:
UniProtKB/Swiss-Prot: Q9UHV2.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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