Rabbit Anti-SCN10A/Nav1.8/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-SCN10A/Nav1.8/FITC Conjugated antibody

mPN3; Peripheral nerve sodium channel 3; Pn3 (gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns (gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X alpha subunit; Voltage-gated sodium channel alpha subu

Cat:

SL6685R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human SCN10A/NAV1.8

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

215kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms.

Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.

Subunit:
The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.

Subcellular Location:
Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10.

Tissue Specificity:
Expressed in the dorsal root ganglia and sciatic nerve.

Post-translational modifications:
Ubiquitinated by NEDD4L; which promotes its endocytosis.

Similarity:
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Contains 1 IQ domain.

Database links:

Entrez Gene: 6336 Human

Entrez Gene: 20264 Mouse

Entrez Gene: 29571 Rat

Omim: 604427 Human

SwissProt: Q9Y5Y9 Human

SwissProt: P70276 Mouse

SwissProt: Q6QIY3 Mouse

SwissProt: Q62968 Rat

Unigene: 250443 Human

Unigene: 10246 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall