background:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death.
Tissue specificity: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.
Subunit:
Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein.
Subcellular Location:
Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Tissue Specificity:
Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
Post-translational modifications:
'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy.
Similarity:
Belongs to the SEC20 family.
Database links:
Entrez Gene: 662 Human
Entrez Gene: 224630 Mouse
Entrez Gene: 140932 Rat
Omim: 603291 Human
SwissProt: Q12981 Human
SwissProt: Q6QD59 Mouse
SwissProt: Q8VHI8 Rat
Unigene: 145726 Human
Unigene: 21795 Mouse
Unigene: 16757 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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