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Rabbit Anti-KCNK3/FITC Conjugated antibody
background:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008].
Function:
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Database links:
Entrez Gene: 3777 Human
Entrez Gene: 16527 Mouse
Entrez Gene: 29553 Rat
Omim: 603220 Human
SwissProt: O14649 Human
SwissProt: Q53SU2 Human
SwissProt: O35111 Mouse
SwissProt: O54912 Rat
Unigene: 645288 Human
Unigene: 439936 Mouse
Unigene: 15536 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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