background:
HOXA9 is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa 9 markedly expands hematopoietic stem cells. HOXA9 expression changes dramatically with age - a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty.
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Abd-B homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 396096 Chicken
Entrez Gene: 100725915 Guinea pig
Entrez Gene: 645 Human
Entrez Gene: 15405 Mouse
Entrez Gene: 500126 Rat
Omim: 142956 Human
SwissProt: Q98924 Chicken
SwissProt: P51783 Guinea pig
SwissProt: P31269 Human
SwissProt: P09631 Mouse
Unigene: 659350 Human
Unigene: 4694 Mouse
Unigene: 203714 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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