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Rabbit Anti-Upstream Binding Protein 1/FITC Conjugated antibody
background:
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HISLV1 initiation site and weakly over the TATA-box. Represses HISLV1 transcription by inhibiting the binding of TFIID to the TATA-box.
Function:
UBP1 is an important SF1 independent transcriptional activator stimulating P450scc expression in human placental JEG 3 cells.
Subunit:
Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 and HeLa cell lines.
Similarity:
Belongs to the grh/CP2 family. CP2 subfamily.
Database links:
Entrez Gene: 7342 Human
Entrez Gene: 22221 Mouse
Entrez Gene: 301038 Rat
Omim: 609784 Human
SwissProt: Q86Y57 Human
SwissProt: Q9NZI7 Human
SwissProt: Q60786 Mouse
SwissProt: Q811S7 Mouse
SwissProt: Q8SH21 Mouse
Unigene: 23641 Human
Unigene: 729120 Human
Unigene: 28052 Mouse
Unigene: 381368 Mouse
Unigene: 15705 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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