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Rabbit Anti-MAOA/FITC Conjugated antibody
background:
Monoamine oxidase A (MAO-A) catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAO-A preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are a cause of Brunner syndrome which is a form of X-linked nondysmorphic mild mental retardation.
Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Subcellular Location:
Mitochondrion outer membrane.
Tissue Specificity:
Heart, liver, duodenum, blood vessels and kidney.
DISEASE:
Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
Similarity:
Belongs to the flavin monoamine oxidase family.
Database links:
Entrez Gene: 4128 Human
Entrez Gene: 17161 Mouse
Entrez Gene: 29253 Rat
Omim: 309850 Human
SwissProt: P21397 Human
SwissProt: Q64133 Mouse
SwissProt: P21396 Rat
Unigene: 183109 Human
Unigene: 21108 Mouse
Unigene: 224544 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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