Home
>
Product
>
Antibody
>
Rabbit Anti-BMP15/FITC Conjugated antibody
background:
The BMP15 protein is a member of the bone morphogenetic protein family which is part of the transforming growth factor beta superfamily. The transforming growth factor beta superfamily includes large families of growth and differentiation factors. It is thought that BMP15 may be involved in oocyte maturation and follicular development as a homodimer, or by forming heterodimers with a related protein, Gdf9.
Function:
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Subunit:
Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.
Subcellular Location:
Secreted.
DISEASE:
Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Similarity:
Belongs to the TGF-beta family.
Database links:
Entrez Gene: 9210 Human
Entrez Gene: 12155 Mouse
Entrez Gene: 59302 Rat
Omim: 300247 Human
SwissProt: O95972 Human
SwissProt: Q9Z0L4 Mouse
Unigene: 532692 Human
Unigene: 42160 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|