background:
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue Specificity:
Epidermis, tongue, tonsil, esophagus and carcinomas.
Similarity:
Contains 4 cadherin domains.
Database links:
UniProtKB/Swiss-Prot: P32926.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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