Rabbit Anti-PAI1/FITC Conjugated antibody

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Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serpin E1; Serpin peptidase inhibitor

Cat:

SL6562R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Dog,Pig,Cow,Horse,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human PAI1/PLANH1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Function:
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Subunit:
Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells

DISEASE:
Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) . It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 5054 Human

Entrez Gene: 18787 Mouse

Entrez Gene: 24617 Rat

Omim: 17372 Human

SwissProt: P05121 Human

SwissProt: P22777 Mouse

SwissProt: P20961 Rat

Unigene: 414795 Human

Unigene: 713079 Human

Unigene: 250422 Mouse

Unigene: 29367 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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