background:
This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]
Function:
May act as a transcription regulator. When overexpressed, promotes entry of cells into S phase and cell proliferation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in osteosarcoma cancer cell line (at protein level). breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines.
Similarity:
Belongs to the Nanog homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 388112 Human
SwissProt: Q6NSW7 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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