background:
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311)
Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Heart, gut, kidney, liver and placenta.
Similarity:
Belongs to the NMT family.
Database links:
UniProtKB/Swiss-Prot: P30419.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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