background:
MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.
Function:
Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization.
Tissue Specificity:
Widely expressed in normal tissues. Down-regulated in multiple primary tumors.
Similarity:
Contains 1 MARVEL domain.
Database links:
UniProtKB/Swiss-Prot: Q9BSK0.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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