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Rabbit Anti-ID1/FITC Conjugated antibody
background:
ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation and angiogenesis. Id1 mRNA is highly expressed in heart, lung and kidney and has lower expression in brain and liver. Two transcript variants encoding different isoforms have been found for this gene.
Function:
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Subunit:
Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity).
Subcellular Location:
Cytoplasm (By similarity). Nucleus.
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
Database links:
Entrez Gene: 3397 Human
Entrez Gene: 15901 Mouse
Entrez Gene: 25261 Rat
Omim: 600349 Human
SwissProt: P41134 Human
SwissProt: P20067 Mouse
SwissProt: P41135 Rat
Unigene: 50929 Human
Unigene: 444 Mouse
Unigene: 2113 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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