Rabbit Anti-SKALP/FITC Conjugated antibody

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ELAF_HUMAN; Elafin; Elastase Specific Inhibitor; Elastase-specific inhibitor; ES 1; ESI; Peptidase inhibitor 3; PI 3; PI-3; PI3; Protease inhibitor 3 skin derived; Protease inhibitor WAP3; SKALP; Skin derived Anti leukoproteinase; Skin-derived antileukopr

Cat:

SL6531R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human SKALP/Elafin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

13kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]

Function:
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Subcellular Location:
Secreted.

Similarity:
Contains 1 WAP domain.

Database links:

Entrez Gene: 5266 Human

Omim: 182257 Human

SwissProt: P19957 Human

Unigene: 112341 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Elafin,又称SKALP(Skin-derived antileucoproteinase)或弹性蛋白酶特异性抑制剂(Elastase-Specific Inhibitor,ESI),它是一种低分子量的弹性蛋白酶抑制剂。它属于“trappin”蛋白家族Trappin-2,具有拮抗胰弹性蛋白酶、中性粒细胞弹性蛋白酶(NE)和蛋白酶3的作用。

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