Home
>
Product
>
Antibody
>
Rabbit Anti-CKMT/FITC Conjugated antibody
background:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subunit:
Exists as an octamer composed of four MTCK homodimers.
Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Similarity:
Belongs to the ATP:guanido phosphotransferase family.
Contains 1 phosphagen kinase SLCterminal domain.
Contains 1 phosphagen kinase N-terminal domain.
Database links:
Entrez Gene: 1159 Human
Entrez Gene: 29593 Rat
Omim: 123290 Human
SwissProt: P12532 Human
Unigene: 425633 Human
Unigene: 155589 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|