Rabbit Anti-CACNB1/FITC Conjugated antibody

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CAB1; CACNLB1; Calcium channel voltage dependent beta 1 subunit; Voltage dependent L type calcium channel beta 1 subunit; CACB1_HUMAN.

Cat:

SL6517R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human CACNB1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

66kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 (By similarity).

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.

Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 327703 Cow

Entrez Gene: 782 Human

Entrez Gene: 12295 Mouse

Entrez Gene: 50688 Rat

Omim: 114207 Human

SwissProt: Q9MZL7 Cow

SwissProt: Q02641 Human

SwissProt: Q8R3Z5 Mouse

SwissProt: P19517 Rabbit

SwissProt: P54283 Rat

Unigene: 635 Human

Unigene: 41252 Mouse

Unigene: 9417 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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