Rabbit Anti-Testin/FITC Conjugated antibody

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Testin; TES; TESS 2; TESS; TESS2; TESS-2; Testis derived transcript (3 LIM domains); Testis derived transcript; TES_HUMAN.

Cat:

SL6502R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Testin (161-210aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

48kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Cancer-associated chromosomal changes often involveregions containing fragile sites. This gene maps to a commomfragile site on chromosome 7q31.2 designated FRA7G. This gene issimilar to mouse Testin, a testosterone-responsive gene encoding aSertoli cell secretory protein containing three LIM domains. LIMdomains are double zinc-finger motifs that mediate protein-proteininteractions between transcription factors, cytoskeletal proteinsand signaling proteins. This protein is a negative regulator ofcell growth and may act as a tumor suppressor. This scaffoldprotein may also play a role in cell adhesion, cell spreading andin the reorganization of the actin cytoskeleton. Multiple proteinisoforms are encoded by transcript variants of this gene.

Function:
Scaffold protein that may play a role in cell adhesion,cell spreading and in the reorganization of the actin cytoskeleton.Plays a role in the regulation of cell proliferation. May act as atumor suppressor. Inhibits tumor cell growth.

Subunit:
Interacts via LIM domain 1 with ZYX. Interacts (via LIMdomain 3) with ENAH and VASP. Interacts with talin, actin,alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) withACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimerinteracts with ENAH to form a heterotrimer.

Subcellular Location:
Cytoplasm. Cell junction, focal adhesion.Note=Detected along actin stress fibers.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the prickle / espinas / testin family.
Contains 3 LIM zinc-binding domains.
Contains 1 PET domain.

Database links:

Entrez Gene: 534965 Cow

Entrez Gene: 26136 Human

Entrez Gene: 21753 Mouse

Entrez Gene: 500040 Rat

Omim: 606085 Human

SwissProt: Q2YDE9 Cow

SwissProt: Q2QLB2 Horse

SwissProt: Q9UGI8 Human

SwissProt: P47226 Mouse

SwissProt: Q2QLE3 Pig

SwissProt: Q2LAP6 Rat

Unigene: 592286 Human

Unigene: 664957 Human

Unigene: 436548 Mouse

Unigene: 44847 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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