Home
>
Product
>
Antibody
>
Rabbit Anti-TEM7R/FITC Conjugated antibody
background:
TEM7R also known as PLXDC2 is a 529 amino acid single-pass type I membrane protein containing one PSI domain and belonging to the plexin family. Localizing to membrane, TEM7R is expressed in endothelial cells of the stroma, as well as in limbs, lung buds, developing heart, spinal cord and dorsal root ganglia. TEM7R interacts with cortactin and may play a role in tumor angiogenesis. Existing as three alternatively spliced isoforms, the gene encoding TEM7R maps to human chromosome 10p12.31. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Function:
May play a role in tumor angiogenesis.
Subunit:
Interacts with CTTN.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Tissue Specificity:
Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.
Similarity:
Belongs to the plexin family.
Contains 1 PSI domain.
Database links:
Entrez Gene: 84898 Human
Entrez Gene: 67448 Mouse
Entrez Gene: 361282 Rat
Omim: 606827 Human
SwissProt: Q6UX71 Human
SwissProt: Q9DC11 Mouse
Unigene: 658134 Human
Unigene: 313938 Mouse
Unigene: 394655 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|