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Rabbit Anti-Rab25/FITC Conjugated antibody
background:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
Function:
Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia. Increases the rates of ovarian and breast cancersprogression and aggressiveness by modulating cellular processessuch as proliferation, survival and migration of epithelial tumorcells. May selectively regulate the apical recycling pathway.Together with MYO5B regulates transcytosis
Subunit:
Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 andRAB11FIP4. Interacts (via the hypervariable SLCterminal region) withITGB1 (via the cytoplasmic region); the interaction isGTP-dependent. Interacts with ITGAV. Associates with the integrinalpha-V/beta-1 heterodimer.
Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmicside (Potential). Cell projection, pseudopodium membrane.Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1in vesicles at the pseudopodial tips.
Tissue Specificity:
Expressed in ovarian epithelium (NOE) andbreast tissue. Expressed in ovarian cancer; expression is increasedrelative to NOE cells. Expression in ovarian cancer is stagedependent, with stage III and stage IV showing higher levels thanearly stage cancers. Expressed in breast cancer; expression isincreased relative to normal breast tissue.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
Database links:
Entrez Gene: 57111 Human
Entrez Gene: 53868 Mouse
Omim: 612942 Human
SwissProt: P57735 Human
SwissProt: Q9WTL2 Mouse
SwissProt: P46629 Rabbit
Unigene: 632469 Human
Unigene: 26994 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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