background:
UEV3, also known as EV and lactate/malate dehydrogenase domain-containing protein, is a 471 amino acid protein that contains one UEV (ubiquitin E2 variant) domain, which typically interacts with ubiquitin. UEV3 is thought to be a paralogue of tsg 101, a protein that exerts regulatory effects on E2 activity in cellular ubiquitination processes. With amino-terminal homology to the catalytic domain of ubiquitin-conjugating enzymes, it is thought that UEV3 may function as a negative regulator of polyubiquitination. UEV3 is expressed in various colon carcinoma cell lines, carcinomas of the uterine cervix and peripheral blood leukocytes as well as normal colon and cervical epithelium.
Subunit:
Homodimer.
Tissue Specificity:
Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.
Similarity:
In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
In the SLCterminal section; belongs to the LDH/MDH superfamily.
Contains 1 UEV (ubiquitin E2 variant) domain.
Database links:
UniProtKB/Swiss-Prot: Q8IX04.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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