Rabbit Anti-TMPRSS4/FITC Conjugated antibody

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MT SP2; Membrane type serine protease 2; TMPRSS 4; TMPRSS3; Transmembrane protease, serine 4; Transmembrane serine protease 3; UNQ776/PRO1570; TMPS4_HUMAN.

Cat:

SL6286R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TMPRSS4 (84-130aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

48kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TMPRSS4 is a member of the peptidase S1 family and contains 1 LDL receptor class A domain, 1 peptidase S1 domain and 1 SRCR domain. It is a probable membrane protease capable of activating ENaC and may process sodium channels in endothelial cells. TMPRSS4 is overexpressed in thyroid neoplasms, and splice variants in TMPRSS4 are thought to be linked with different cancers. Three named isoforms are produced by alternative splicing.

Function:
Probable protease. Seems to be capable of activating ENaC.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).

Tissue Specificity:
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.

Database links:

Entrez Gene: 451581 Chimpanzee

Entrez Gene: 489387 Dog

Entrez Gene: 101147411 Gorilla

Entrez Gene: 100071190 Horse

Entrez Gene: 56649 Human

Entrez Gene: 100390415 Marmoset (common)

Entrez Gene: 100436934 Orangutan

Omim: 606565 Human

SwissProt: Q9NRS4 Human

Unigene: 161985 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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