background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Subcellular Location:
Secreted
Tissue Specificity:
Expression is restricted to the brain, and more specifically to the forebrain.
Similarity:
Belongs to the Wnt family.
Database links:
Entrez Gene: 7479 Human
Entrez Gene: 538720 Cow
Entrez Gene: 486841 Dog
Entrez Gene: 10007072 Horse
Omim: 601396 Human
SwissProt: Q93098 Human
Unigene: 421281 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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