Rabbit Anti-HOMER2/FITC Conjugated antibody

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ACPD; CPD; Cupidin; HOME2_HUMAN; HOMER 2; HOMER 2A; HOMER 2B; Homer homolog 2 (Drosophila); Homer homolog 3; Homer neuronal immediate early gene 2; Homer protein homolog 2; Homer-2; Homer2; HOMER2A; HOMER2B; Vesl 2; Vesl2.

Cat:

SL4632R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human HOMER2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

Subunit:
Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Subcellular Location:
Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Similarity:
Belongs to the Homer family.
Contains 1 WH1 domain.

Database links:

Entrez Gene: 510811 Cow

Entrez Gene: 9455 Human

Entrez Gene: 26557 Mouse

Entrez Gene: 29547 Rat

Omim: 604799 Human

SwissProt: Q9NSB8 Human

SwissProt: Q9QWW1 Mouse

SwissProt: O81761 Rat

Unigene: 578443 Human

Unigene: 228 Mouse

Unigene: 30014 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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