background:
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
Subunit:
Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
Tissue Specificity:
Widely expressed.
DISEASE:
Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13) [MIM:614070]. PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Similarity:
Contains 1 SEFIR domain.
Database links:
Entrez Gene: 10758 Human
Entrez Gene: 103213 Mouse
Entrez Gene: 361857 Rat
Omim: 607043 Human
SwissProt: O43734 Human
Unigene: 561514 Human
Unigene: 436686 Mouse
Unigene: 9031 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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