background:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008].
Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Subunit:
Interacts with ATP6AP2.
Subcellular Location:
Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
DISEASE:
Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
Similarity:
Belongs to the peptidase A1 family.
Database links:
Entrez Gene: 469651 Chimpanzee
Entrez Gene: 5972 Human
Entrez Gene: 19701 Mouse
Entrez Gene: 19702 Mouse
Entrez Gene: 24715 Rat
Omim: 179820 Human
SwissProt: P60016 Chimpanzee
SwissProt: Q6DLS0 Cynomolgus Monkey
SwissProt: P00797 Human
SwissProt: P00796 Mouse
SwissProt: P06281 Mouse
SwissProt: P08424 Rat
Unigene: 3210 Human
Unigene: 220955 Mouse
Unigene: 9831 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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