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Rabbit Anti-RBP4/FITC Conjugated antibody
background:
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008].
Function:
Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Subcellular Location:
Secreted.
DISEASE:
Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:36250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
Similarity:
Belongs to the calycin superfamily. Lipocalin family.
Database links:
Entrez Gene: 5950 Human
Omim: 36250 Human
SwissProt: P02753 Human
Unigene: 50223 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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