Rabbit Anti-APBB1 interacting protein 1/FITC Conjugated antibody

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AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; OTTHUMP00000019344; PREL 1; PREL1; Proline rich EVH1 ligand 1; Proline rich prot

Cat:

SL6172R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RIAM/APBB1 interacting protein 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

73kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion. APBB1IP also interacts with RAP 1A, Profilin-1, VASP and Mena.

Function:
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Subunit:
nteracts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.

Subcellular Location:
Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.

Tissue Specificity:
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.

Similarity:
Belongs to the MRL family.
Contains 1 PH domain.

Database links:

Entrez Gene: 54518 Human

Entrez Gene: 54519 Mouse

Omim: 609036 Human

SwissProt: Q7Z5R6 Human

SwissProt: Q8R5A3 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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