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Rabbit Anti-NET1/FITC Conjugated antibody
background:
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Function:
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Subunit:
Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1.
Subcellular Location:
Cytoplasm (By similarity). Nucleus
Tissue Specificity:
Widely expressed.
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Database links:
Entrez Gene: 10276 Human
SwissProt: Q7Z628 Human
Unigene: 25155 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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