Rabbit Anti-RUNX1T1/FITC Conjugated antibody

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Acute myelogenous leukemia 1 translocation 1 cyclin D related; Acute myelogenous leukemia 1 translocation 1 protein; AML1T1; CBFA2T1; CDR; Core binding factor runt domain alpha subunit 2 translocated to 1; Core binding factor runt domain alpha subunit 2 t

Cat:

SL6101R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human RUNX1T1/ETO

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

66kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Subunit:
Homotetramer. Heterotetramer with CSFA2T2 and CSFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression.

Subcellular Location:
Nucleus.

Tissue Specificity:
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.

Similarity:
Belongs to the CSFA2T family.
Contains 1 MYND-type zinc finger.
Contains 1 TAFH (NHR1) domain.

Database links:

Entrez Gene: 862 Human

Entrez Gene: 12395 Mouse

Entrez Gene: 362489 Rat

Omim: 133435 Human

SwissProt: Q06455 Human

SwissProt: Q61909 Mouse

Unigene: 368431 Human

Unigene: 470961 Mouse

Unigene: 4909 Mouse

Unigene: 218117 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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