background:
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
Function:
The precursor protein but not the mature protein may form multimers.
Subunit:
The precursor protein but not the mature protein may form multimers.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Post-translational modifications:
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
Similarity:
Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain.
Database links:
Entrez Gene: 255738 Human
Entrez Gene: 100102 Mouse
Entrez Gene: 298296 Rat
Omim: 607786 Human
SwissProt: Q8NBP7 Human
SwissProt: Q80W65 Mouse
SwissProt: P59996 Rat
Unigene: 18844 Human
Unigene: 133268 Mouse
Unigene: 19195 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
前蛋白转化酶枯草溶菌素9(PCSK9)是近年来新发现的一种与调节脂质代谢密切相关的基因,编码前蛋白转化酶NARSLC1。Narc-1/pcsk9可通过调节细胞表面的低密度脂蛋白受体(LDLR)水平,参与脂质代谢,从而在动脉粥样硬化性疾病的发生、发展中发挥重要作用。
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