background:
A2MRAP;
A2RAP;
Alpha 2 macroglobulin receptor associated protein;
Alpha 2 MRAP;
HBP44;
Lipoprotein receptor associated protein;
Low density lipoprotein receptor related protein associated protein 1;
Low density lipoprotein related protein associated protein 1 alpha 2 macroglobulin receptor associated protein;
Low density lipoprotein related protein associated protein 1;
LRPAP1;
MRAP;
RAP.
Function:
Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Subunit:
Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation.
Subcellular Location:
Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.
Post-translational modifications:
N-glycosylated.
DISEASE:
Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
Similarity:
Belongs to the alpha-2-MRAP family.
Database links:
UniProtKB/Swiss-Prot: P30533.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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