background:
FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found.
Function:
UniProtKB/Swiss-Prot: Q8N441.1
FASTA Graphics
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LOCUS FGRL1_HUMAN 504 aa linear PRI 01-MAY-2013
DEFINITION RecName: Full=Fibroblast growth factor receptor-like 1; Short=FGF
receptor-like protein 1; AltName: Full=FGF homologous factor
receptor; AltName: Full=FGFR-like protein; AltName: Full=Fibroblast
growth factor receptor 5; Short=FGFR-5; Flags: Precursor.
Subunit:
Interacts with FGF2 with a low affinity.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
UniProtKB/Swiss-Prot: Q8N441.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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