Rabbit Anti-CA12/FITC Conjugated antibody

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CA 12; CA XII; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII; Carbonic dehydratase; CAXII; Tumor antigen HOM RCC 3.1.3.

Cat:

SL6025R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human CA12(258-295aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CA12 (Carbonic anhydrase XII) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide.

Function:
Reversible hydration of carbon dioxide.

Subunit:
Homodimer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.

DISEASE:
Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.

Similarity:
Belongs to the alpha-carbonic anhydrase family.

Database links:

Entrez Gene: 771 Human

Omim: 603263 Human

SwissProt: O43570 Human

Unigene: 210995 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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