Rabbit Anti-FBXO31/FITC Conjugated antibody

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F box only protein 31; FBX14; FBX31; FBXO14; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor; FBX31_HUMAN.

Cat:

SL6006R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FBXO31 (170-225aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

61kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
FBXO31 belongs to the F-box protein family. Such proteins are characterized by an F-box motif of approximately 40 residues. F-box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains. There are two different isoforms.

Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Tissue Specificity:
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.

Post-translational modifications:
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.

Similarity:
Belongs to the FBXO31 family.
Contains 1 F-box domain.

Database links:

Entrez Gene: 79791 Human

Entrez Gene: 76454 Mouse

Omim: 609102 Human

SwissProt: Q5XUX0 Human

SwissProt: Q3TQF0 Mouse

Unigene: 567582 Human

Unigene: 467749 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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