background:
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Function:
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Subunit:
Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP36, HDAC1 and HDAC2.
Subcellular Location:
Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells.
Tissue Specificity:
Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
Similarity:
Contains 1 ARID domain.
Database links:
UniProtKB/Swiss-Prot: Q4LE39.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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