background:
SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Function:
NAD-dependent protein deacetylase. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex.
Subunit:
Interacts with UBTF and the RNA polymerase I complex. Interacts with histone H2A and/or histone H2B.
Subcellular Location:
Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Post-translational modifications:
Phosphorylated during mitosis (Probable).
Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.
Database links:
Entrez Gene: 505662 Cow
Entrez Gene: 51547 Human
Entrez Gene: 209011 Mouse
Omim: 606212 Human
SwissProt: Q0P595 Cow
SwissProt: Q9NRC8 Human
SwissProt: Q8BKJ9 Mouse
Unigene: 514636 Human
Unigene: 292957 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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