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Rabbit Anti-B MyB/FITC Conjugated antibody
background:
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in the regulation of cell survival, proliferation, and differentiation.
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes.
Subunit:
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
Subcellular Location:
Nucleus.
Tissue Specificity:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Similarity:
Contains 3 HTH myb-type DNA-binding domains.
Database links:
Entrez Gene: 925 Human
Entrez Gene: 17865 Mouse
Entrez Gene: 296344 Rat
Omim: 601415 Human
SwissProt: P10244 Human
SwissProt: P48972 Mouse
Unigene: 179718 Human
Unigene: 4594 Mouse
Unigene: 20824 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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