Rabbit Anti-SERINC3/FITC Conjugated antibody

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TMS 1; TMS-1; AIGP1; DIFF33; SBBI99; serine incorporator 3; TDE; TDE1; Tumor differentially expressed protein 1; SERC3_HUMAN.

Cat:

SL5942R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Dog,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human SERINC3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

53kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.

Function:
May be involved in cellular transformation.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the TDE1 family.

Database links:

Entrez Gene: 10955 Human

Entrez Gene: 26943 Mouse

Entrez Gene: 296350 Rat

Omim: 607165 Human

SwissProt: Q13530 Human

SwissProt: Q9QZI9 Mouse

Unigene: 272168 Human

Unigene: 218473 Mouse

Unigene: 3775 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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