background:
This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011].
Function:
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Subunit:
Interacts with BRI3BP.
Subcellular Location:
Mitochondrion outer membrane; Single-pass membrane protein.
Tissue Specificity:
Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
Similarity:
Contains 1 LETM1 domain.
Database links:
UniProtKB/Swiss-Prot: Q6P1Q0
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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