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Rabbit Anti-GASC1/KDM4C/FITC Conjugated antibody
background:
KDM4C/JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates Lysine 9 and Lysine 36 residues of Histone H3, thereby playing a central role in regulating histone modifications.
Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular Location:
Nucleus.
Tissue Specificity:
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Similarity:
Belongs to the JHDM3 histone demethylase family.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 2 PHD-type zinc fingers.
Contains 2 Tudor domains.
Database links:
Entrez Gene: 23081 Human
Entrez Gene: 71364 Mouse
Entrez Gene: 298144 Rat
Omim: 605469 Human
SwissProt: Q9H3R0 Human
SwissProt: Q8VCD7 Mouse
Unigene: 709425 Human
Unigene: 209059 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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