background:
KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents.
Function:
pH-dependent, voltage-insensitive, background potassium channel protein.
Subcellular Location:
Membrane; Multi-pass membrane protein
Tissue Specificity:
Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.
DISEASE:
Defects in KCNK9 are the cause of Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM:612292]. A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8)
Database links:
Entrez Gene: 428382 Chicken
Entrez Gene: 51305 Human
Omim: 605874 Human
SwissProt: Q9NPC2 Human
Unigene: 493037 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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