Rabbit Anti-IMPDH2/FITC Conjugated antibody

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IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; Impdh2; IMPDHII; Inosine 5' monophosphate dehydrogenase 2; Inosine-5''-monophosphate dehydrogenase 2; IMDH2_HUMAN.

Cat:

SL5924R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human IMPDH2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

56kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Subunit:
Homotetramer.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Database links:

Entrez Gene: 3615 Human

Entrez Gene: 23918 Mouse

Entrez Gene: 301005 Rat

Omim: 146691 Human

SwissProt: P12268 Human

SwissProt: P24547 Mouse

SwissProt: E9PU28 Rat

Unigene: 65880 Human

Unigene: 6065 Mouse

Unigene: 8093 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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