Rabbit Anti-PDLIM3/FITC Conjugated antibody

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ALP; Actinin associated LIM protein; Actinin-associated LIM protein; Alpha actinin 2 associated LIM protein; Alpha-actinin-2-associated LIM protein; DKFZp686L0362; Enigma homolog; PDLI3_HUMAN; PDLIM 3; PDLIM-3; PDLIM3; PDZ and LIM domain 3; PDZ and LIM do

Cat:

SL2928R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PDLIM3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.

Function:
May play a role in the organization of actin filament arrays within muscle cells.

Subunit:
Interacts with ACTN2.

Subcellular Location:
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.

Tissue Specificity:
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.

Similarity:
Contains 1 LIM zinc-binding domain.
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 538516 Cow

Entrez Gene: 27295 Human

Entrez Gene: 53318 Mouse

Entrez Gene: 114108 Rat

Omim: 605889 Human

SwissProt: Q3SYZ8 Cow

SwissProt: Q53GG5 Human

SwissProt: O70209 Mouse

SwissProt: Q66HS7 Rat

Unigene: 442702 Human

Unigene: 731826 Human

Unigene: 28580 Mouse

Unigene: 13361 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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