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Rabbit Anti-HIF Prolyl Hydroxylases/FITC Conjugated antibody
background:
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subunit:
Homodimer.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Post-translational modifications:
Glycosylated.
Similarity:
Contains 2 EF-hand domains.
Contains 1 Fe2OG dioxygenase domain.
Database links:
Entrez Gene: 54681 Human
Entrez Gene: 74443 Mouse
Omim: 614584 Human
SwissProt: Q9NXG6 Human
SwissProt: Q8BG58 Mouse
Unigene: 654944 Human
Unigene: 226534 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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