background:
CTHRC1 is a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
Function:
May act as a negative regulator of collagen matrix deposition (By similarity).
Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).
Tissue Specificity:
Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.
Post-translational modifications:
N-glycosylated (By similarity).
DISEASE:
Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Similarity:
Contains 1 collagen-like domain.
Database links:
UniProtKB/Swiss-Prot: Q96CG8.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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