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Rabbit Anti-ANKHD1/FITC Conjugated antibody
background:
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.
Function:
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.
Subunit:
Interacts with PTPN11. Isoform 2 interacts with HISLV1 VPR.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain.
Similarity:
Belongs to the mask family.
Contains 25 ANK repeats.
Contains 1 KH domain.
Database links:
Entrez Gene: 54882 Human
Omim: 610500 Human
SwissProt: Q8IWZ3 Human
Unigene: 594084 Human
Unigene: 720987 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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