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Rabbit Anti-LOXL4/FITC Conjugated antibody
background:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the SLCterminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Function:
May modulate the formation of a collagenous extracellular matrix.
Subcellular Location:
Secreted, extracellular space
Tissue Specificity:
Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
Post-translational modifications:
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Similarity:
Belongs to the lysyl oxidase family.
Contains 4 SRCR domains.
Database links:
Entrez Gene: 84171 Human
Entrez Gene: 67573 Mouse
Omim: 607318 Human
SwissProt: Q96JB6 Human
SwissProt: Q924C6 Mouse
Unigene: 306814 Human
Unigene: 671890 Human
Unigene: 178767 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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