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Rabbit Anti-TGFB4/LEFTY2/FITC Conjugated antibody
background:
LEFTY2 is a member of the TGF-beta family of proteins. LEFTY2 is secreted and plays a role in left-right asymmetry determination of organ systems during development and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
Function:
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Subcellular Location:
Secreted.
Tissue Specificity:
Mesenchymal cells of the endometrial stroma.
Post-translational modifications:
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
DISEASE:
Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
Similarity:
Belongs to the TGF-beta family.
Database links:
Entrez Gene: 7044 Human
Entrez Gene: 64202 Mouse
Entrez Gene: 289316 Rat
Omim: 601877 Human
SwissProt: O00292 Human
SwissProt: P57785 Mouse
Unigene: 520187 Human
Unigene: 87078 Mouse
Unigene: 215726 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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